AUTOANTIBODIES TO GLUTAMIC ACID DECARBOXYLASE AS A PATHOGENETIC MARKER OF TYPE I DIABETES MELLITUS
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چکیده
منابع مشابه
INVESTIGATION ON ANTI-GLUTAMIC ACID DECARBOXYLASE ANTIBODIES IN TYPE I DIABE TES MELLITUS
Antibodies directed against the enzyme glutamic acid decarboxylase (GAD) are believed to be the main cause of destruction of pancreatic islet cells in type I (insulin dependent) diabetes mellitus. The enzyme was found both in the brain and pancreatic beta cells. Although similarities in identity of GAD in human and rat brain have been demonstrated, little is known about the interaction betw...
متن کاملRelationship between the prevalence of anti-glutamic acid decarboxylase autoantibodies and duration of type 1 diabetes mellitus in Brazilian patients.
The objective of the present study was to determine whether the duration of disease has any influence on the prevalence of glutamic acid decarboxylase autoantibodies (GADA) in Brazilian patients with type 1 diabetes (T1D) and variable disease duration. We evaluated 83 patients with T1D. All participants were interviewed and blood was obtained for GADA measurement by a commercial radioimmunoassa...
متن کاملinvestigation on anti-glutamic acid decarboxylase antibodies in type i diabe tes mellitus
antibodies directed against the enzyme glutamic acid decarboxylase (gad) are believed to be the main cause of destruction of pancreatic islet cells in type i (insulin dependent) diabetes mellitus. the enzyme was found both in the brain and pancreatic beta cells. although similarities in identity of gad in human and rat brain have been demonstrated, little is known about the interaction between ...
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The cause of downbeat nystagmus (DBN) remains undiagnosed in about 40% of patients. This paper reports the presence of antiglutamic acid decarboxylase antibodies (GAD-Ab) in a patient with DBN. Antibodies against GABAergic neurons located in the vestibular complex may induce chemical denervation of the floccular neurons, which normally suppress the peripheral imbalance between vertical semicirc...
متن کاملAntibodies to glutamic acid decarboxylase discriminate major types of diabetes mellitus.
Insulin-dependent diabetes mellitus (IDDM) is marked by circulating antibodies to a 64,000-M(r) islet cell antigen identified as glutamic acid decarboxylase (GAD). We describe a radioimmunoprecipitation assay with GAD isolated from pig brain. The sera tested were from 80 patients with IDDM including 26 with disease of recent onset and 54 with disease of longer duration (3-42 yr), 20 with non-in...
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ژورنال
عنوان ژورنال: Medical Immunology (Russia)
سال: 2014
ISSN: 2313-741X,1563-0625
DOI: 10.15789/1563-0625-2011-2-3-257-260